A process for preparing 3-hydroxythiolane which is characterized by reacting a compound of the following formula, ???wherein X is a halogen atom, and R2 is a substituted or unsubstituted alkyl group, substituted or unsubstituted aralkyl group, or substituted or unsubstituted aryl group, with a metal sulfide.
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Page/Page column 3-4
(2008/06/13)
Process for preparing optically active 3-hydroxypyrrolidine derivatives
A process for preparing optically active 3-hydroxypyrrolidine derivatives useful as intermediates represented by formula (III): STR1 wherein Q represents a substituted or unsubstituted phenyl group; and * indicates an asymmetric carbon atom, comprising reacting an optically active 4-halo-3-hydroxybutane derivative represented by formula (I): STR2 wherein * is as defined above; R1 represents a lower alkyl group or a substituted or unsubstituted phenyl group; and X represents a halogen atom, with a benzylamine derivative represented by formula (II): wherein Q is as defined above, is disclosed. The starting compound (I) is easily available through chemical synthesis. Any complicated procedure or use of an expensive reagent is not required.
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(2008/06/13)
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