- A method of drying not takes charge of according to Uygur (by machine translation)
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The invention discloses a not takes charge of according to Uygur post treatment method, in particular for the ivermectin Mo-division and crude drying method, the drying method to obtain ivermectin Mo after si Cupin, adding water, solid precipitation, filtration, solid taken out -20 °C storage, preparation, to obtain the pure product after dissolving with ethanol, is added to the purification in the water drop, separating out the filter, solid nitrogen gas at 0 °C under, dry 24 hours. (by machine translation)
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Paragraph 0021; 0022
(2017/08/23)
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- PROCESS FOR MAKING EVEROLIMUS
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An improved process of making the compound everolimus is disclosed. The process is based on a reaction of rapamycin with 2-(t-hexyldimethylsilyloxy)ethyl triflate of formula (3C) in an inert solvent in the presence of a base, to form 40-O-2-(t-hexyldimethylsilyloxy)ethylrapamycin which is deprotected by an acid to form everolimus.
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