- FIVE-MEMBERED 2,3-DIOXOHETEROCYCLES. XXXII. REACTION OF 5-ARYL-4-ACETYL-1-METHYL- AND 4-ALKOXYCARBONYL-1,5-DIARYLTETRAHYDROPYRROL-2,3-DIONES WITH ETHANOLAMINE AND DIALKYLAMINOETHANOLS
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The reactions of methyl acetylpyruvate with aromatic aldehydes and methylamine give 4-acetyl-5-aryl-1-methyltetrahydropyrrole-2,3-diones, which are converted into 5-aryl-4--1-methyltetrahydropyrrole-2,3-diones when treated with ethanolamine.The previously obtained 1,5-diaryl-4-ethoxycarbonyltetrahydropyrrol-2,3-diones form 1:1 adducts with ethanolamine.Heating the latter above their decomposition point leads to formation of 1,5-diaryl-3-(2-hydroxyethylamino)-4-ethoxycarbonyl-2,5-dihydropyrrol-2-ones. 1,5-Diaryl-4-tert-butoxycarbonyltetrahydropyrrole-2,3-diones react with dialkylaminoethanols, yielding 1,5-diaryl-4--3-hydroxy-2,5-dihydropyrrol-2-ones.
- Gein, V.L.,Shumilovskikh, E.V.,Voronina, E.V.,Sarayeva, R.F.,Gein, L.F.,et al.
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p. 1084 - 1089
(2007/10/02)
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