Anionic [4+2] cycloaddition strategy to linear furocoumarins: Synthesis of 8 methoxypsoralen and its isoster
The surfoxide esters 14 and 20d are successfully annulated with bicyclic enone 8 in the presence of (t)BuOLi to provide the pentacyclic ketones 9a and 21a respectively in good yields (≤70%). Flash vacuum pyrolysis of O-methyl derivatives 9b and 21b at - 5000 C/. 1 mm provide furoindacenones 16b and 22b respectively, which in turn are convertible to furocoumarins 1 and 3.
Mal, Dipakranjan,Bandhyopadhyay, Mousumi,Datta,Murty, Kadiyala V. S. N.
p. 7525 - 7538
(2007/10/03)
A Convenient Route to Diazepines by Intramolecular Cyclisation of Carbonylazides
The appriopriate substituted carbonylazides I treated with warm acetic acid give the corresponding acetamide IV or the cyclic lactam VI.This is a convenient route to 10,11-Dihydro-5H-pyrrolobenzodiazepin-11-one and 10,11-Dihydro-4H-thieno2,3-
Daich, Abdelali,Povazanec, Frantisek,Decroix, Bernard
p. 1911 - 1915
(2007/10/02)
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