- On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cells
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Fluorescent quinone-based BODIPY hybrids were synthesised and characterised by NMR analysis and mass spectrometry. We measured their cytotoxic activity against cancer and normal cell lines, performed mechanistic studies by lipid peroxidation and determina
- Gontijo, Talita B.,de Freitas, Rossimiriam P.,Emery, Flavio S.,Pedrosa, Leandro F.,Vieira Neto, José B.,Cavalcanti, Bruno C.,Pessoa, Claudia,King, Aaron,de Moliner, Fabio,Vendrell, Marc,da Silva Júnior, Eufranio N.
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- BODIPY dyes functionalized with pendant cyclic and acyclic polyamines
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The synthesis and characterization of a series of BODIPY derivatives substituted with acyclic and cyclic polyamines, in particular, cyclen and homocyclen, are reported. The 19F NMR, UV/Vis, and fluorescence spectroscopic data of these compounds are discussed. One compound was found to be very selective for CuII ions, which makes it a very promising system for CuII detection. Copyright
- Volkova, Yulia A.,Brizet, Bertrand,Harvey, Pierre D.,Averin, Alexey D.,Goze, Christine,Denat, Franck
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- Fluorescent amino acid based on BODIPY as well as synthetic method and application thereof
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The invention discloses fluorescent amino acid based on BODIPY as well as a synthetic method and an application thereof. A general structural formula of the fluorescent amino acid based on BODIPY is shown in the formula (I) in the specification. The fluorescent amino acid based on BODIPY can be directly applied to polypeptide synthesis and preparation of fluorescence-labelled polypeptide after being prepared and also can structurally induce the polypeptide to form a stable secondary structure, so that the obtained fluorescent polypeptide has certain biological activity, can be directly applied to study of protein-protein interaction as a probe and has a great practical application prospect.
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Paragraph 0080
(2016/10/08)
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- Compound for verifying amino acid capability of inducing polypeptide to form beta-sheet secondary structure and preparation method thereof
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The invention discloses a compound used for verifying amino acid capability of inducing polypeptide to form a beta-sheet secondary structure. The compound is characterized in that its structure is as shown in the formula. By testing whether amino-hydrogen and ketonic oxygen in a compound 2 can form an intramolecular hydrogen bond, whether a compound 1 can induce linked polypeptides to form a stable beta-sheet secondary structure is determined, which is of great guiding significance for determining whether synthesized fluorescent amino acid can be applied in fields of fluorescence kit development, research and development of drugs and the like.
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Paragraph 0058; 0059
(2016/11/21)
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- DYE COMPRISING PYRROMETHENE BORON COMPLEX COMPOUND
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The present invention relates to a dye comprising a pyrromethene boron complex compound. The dye comprising a pyrromethene boron complex according to the present invention does not have fluorescence, and absorbs light of a specific wavelength, thereby being used as a display dye.COPYRIGHT KIPO 2016
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Paragraph 0113; 0114; 0115
(2016/11/17)
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- Synthesis and characterisation of neutral mononuclear cuprous complexes based on dipyrrin derivatives and phosphine mixed-ligands
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Heteroleptic neutral mononuclear cuprous complexes with dipyrrin derivatives and phosphine mixed-ligands including 1,3,7,9-tetramethyldipyrrin (1), 5-phenyl-1,3,7,9-tetramethyldipyrrin (2), 2,8-dibromo-1,3,7,9- tetramethyldipyrrin (3), 1,9-dichloro-5-phen
- Liu, Xiaohui,Nan, Hongmei,Sun, Wei,Zhang, Qikai,Zhan, Mingjian,Zou, Luyi,Xie, Zhiyuan,Li, Xiao,Lu, Canzhong,Cheng, Yanxiang
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p. 10199 - 10210
(2013/01/14)
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