Aryl piperazinyl ureas as inhibitors of fatty acid amide hydrolase (FAAH) in rat, dog, and primate
A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elevate the plasma levels of three fatt
Keith, John M.,Apodaca, Rich,Tichenor, Mark,Xiao, Wei,Jones, William,Pierce, Joan,Seierstad, Mark,Palmer, James,Webb, Michael,Karbarz, Mark,Scott, Brian,Wilson, Sandy,Luo, Lin,Wennerholm, Michelle,Chang, Leon,Brown, Sean,Rizzolio, Michele,Rynberg, Raymond,Chaplan, Sandra,Breitenbucher, J. Guy
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p. 823 - 827,5
(2020/09/15)
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