First iron-catalyzed guanylation of amines: A simple and highly efficient protocol to guanidines
The first iron-catalyzed guanylation of amines is reported. Commercially available Fe(OAc)2 acts as an excellent catalyst for the addition of amines to carbodiimides. The reaction is broadly applicable to a variety of primary, secondary, and heterocyclic amines, and tolerates a wide range of functionalities allowing the easy preparation of a large family of guanidines. The low price and low toxicity of the commercially available iron catalyst make this methodology highly attractive.
Pottabathula, Srinivas,Royo, Beatriz
supporting information; experimental part
p. 5156 - 5158
(2012/09/22)
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