Dipeptidyl peptidase-4 inhibitor with β-amino amide scaffold: Synthesis, SAR and biological evaluation
Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. Several series of β-amino amide containing piperazine derivatives have been prepared and evaluated as a inhibitor of DPP4. Finally compound 5m was selected for further evaluation.
Kim, Heung Jae,Kwak, Woo Young,Min, Jong Pil,Sung, Si Young,Kim, Ha Dong,Kim, Mi Kyung,Kim, Hae Sun,Park, Kyung Jin,Son, Moon Ho,Kim, Soon Hoe,Lee, Bong Jin
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p. 5545 - 5549
(2012/09/22)
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