A class of indole derivatives and preparation methods and uses thereof
The present invention relates to the field of medicinal chemistry, discloses a class of indole derivatives and preparation methods and uses thereof. The present invention also discloses a compound comprising the indole structure or a pharmaceutically acce
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Paragraph 0032; 0039-0040; 0047; 0051-0052
(2022/01/12)
Indole structure-containing compound or pharmaceutically acceptable salt, preparation method and application thereof
The invention discloses an indole structure-containing compound with a structure as shown in a general formula (I) or pharmaceutically acceptable salt, a preparation method and application thereof. The indole structure-containing compound or the pharmaceu
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(2020/08/29)
Phenyl sulfide structure-containing compound or pharmaceutically acceptable salt, preparation method and application thereof
The invention discloses a phenyl sulfide structure-containing compound with a structure as shown in a general formula (I) or pharmaceutically acceptable salt, a preparation method and application thereof. The compound containing the phenyl sulfide structu
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Paragraph 0040; 0046-0047
(2020/08/27)
Scale-up synthesis of antidepressant drug vilazodone
A scale-up synthesis of antidepressant drug vilazodone was accomplished in five steps. Friedel-Crafts acylation of 1-tosyl-1H-indole-5-carbonitrile with 4-chlorobutyryl chloride, selective deoxygenation in NaBH4/CF 3COOH system coupled with ethyl 5-(piperazin-1-yl)-benzofuran-2- carboxylate hydrochloride, one-step deprotection and esterolysis, and the final ammonolysis led to the target molecule vilazodone in 52.4% overall yield and 99.7% purity. This convenient and economical procedure is remarkably applicable for scale-up production.
Hu, Bin,Song, Qiao,Xu, Yungen
p. 1552 - 1557
(2013/02/25)
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