A variety of 1H-isoindole-based peptides was designed as potential mimics, and their efficient synthesis starting from 1-imino-1H-isoindol-3-amine by subsequent interaction with N-Boc-amino acid hydrazides and amino acid ester isocyanates generated in situ, followed by chain elongation using conventional peptide chemistry, was elaborated. A variety of potential peptidomimetics in which the 1H-isoindole unit is coupled by means of a hydrazide linkage from one side and a urea scaffold from other side, was developed. Copyright
Biitseva, Angelina V.,Rudenko, Igor V.,Hordiyenko, Olga V.,Jamart-Gregoire, Brigitte,Arrault, Axelle
experimental part
p. 4387 - 4394
(2012/09/22)
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