- Chemoselective Reduction of Tertiary Amides by 1,3-Diphenyl disiloxane (DPDS)
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A convenient procedure for the chemoselective reduction of tertiary amides at room temperature in the presence of air and moisture using 1,3-diphenyldisiloxane (DPDS) is developed. The reaction conditions tolerate a significant number of functional groups including esters, nitriles, secondary amides, carbamates, sulfoxides, sulfones, sulfonyl fluorides, halogens, aryl-nitro groups, and arylamines. The conditions reported are the mildest to date and utilize EtOAc, a preferred solvent given its excellent safety profile and lower environmental impact. The ease of setup and broad chemoselectivity make this method attractive for organic synthesis, and the results further demonstrate the utility of DPDS as a selective reducing agent.
- Aldrich, Courtney C.,Hammerstad, Travis A.,Hegde, Pooja V.,Wang, Kathleen J.
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- NOVEL ANTIBIOTICS
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Novel aryl compounds or pharmaceutically acceptable salts thereof, and uses of the same for the treatment of Gram-negative infections.
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Page/Page column 32
(2018/02/03)
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- HETERO-HALO INHIBITORS OF HISTONE DEACETYLASE
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This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.
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Paragraph 321
(2017/01/26)
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- Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties
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In an effort to identify a potential back-up to apixaban (Eliquis), we explored a series of diversified P4 moieties. Several analogs with substituted gem-dimethyl moieties replacing the terminal lactam of apixaban were identified which demonstrated potent
- Orwat, Michael J.,Qiao, Jennifer X.,He, Kan,Rendina, Alan R.,Luettgen, Joseph M.,Rossi, Karen A.,Xin, Baomin,Knabb, Robert M.,Wexler, Ruth R.,Lam, Patrick Y.S.,Pinto, Donald J.P.
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p. 3341 - 3345
(2014/07/22)
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- Water-soluble red-emitting distyryl-borondipyrromethene (BODIPY) dyes for biolabeling
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A series of water-soluble red-emitting distyryl-borondipyrromethene (BODIPY) dyes were designed and synthesized by using three complementary approaches aimed at introducing water-solubilizing groups on opposite faces of the fluorescent core to reduce or c
- Niu, Song-Lin,Massif, Cedrik,Ulrich, Gilles,Renard, Pierre-Yves,Romieu, Anthony,Ziessel, Raymond
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scheme or table
p. 7229 - 7242
(2012/07/03)
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- ISOTOPE EXCHANGE OF IODINE IN INACTIVATED IODINE DERIVATIVES OF BENZENE, CATALYZED BY COPPER SALT
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The isotope exchange of iodine in some aromatic iodine compounds was investigated in the presence of copper salts in various solvents at 76.5 deg C.It was shown that monovalent copper is responsible for the catalysis during isotope exchange.The isotope exchange is due to intramolecular coordination of the Cu1+ ion with a molecule of the aromatic iodine compounds.A scheme for the isotope exchange of iodine in iodoarenes in the presence of copper salts, using the idea of a one-electron transfer and coordination action between the d10 metals and the ? systems, is proposed and discussed.
- Iroshnikova, N. G.,Stanko, V. I.
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p. 514 - 520
(2007/10/02)
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- Novel quaternary ammonium salts, compositions and methods for their use
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Para-iodobenzyltrimethylammonium iodide is useful as an intermediate in the manufacture of the corresponding compounds wherein the para-iodo atom is enriched with an 123 iodine, 125 iodine or 131 iodine isotope. These radi
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