- Synthetic method of thiazoles (by machine translation)
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4 - Acetoxy 3 - acetyl -3 - chloropropyl acetate is hydrolyzed under acidic conditions to prepare 4 -mercapto -2 - methyl -2 - (β - acetoxyethyl)-thiazole; the step of preparing -2 - methyl -2 - (β - acetoxyethyl)-thiazole with 3 - methyl -3 - (β - acetoxyethyl)-thiazole under acidic condition is carried out under an acidic condition by adding an oxidizing agent under an acidic condition in 3 -chloro -3 -methyl 2 - (β - acetoxyethyl)-thiazole in an acidic condition under an acidic condition by adding 4 - an oxidizing agent under an acidic condition; and a -5 - method -5 - for synthesizing thiazoles -4 - and -5 -mercapto 2 -methyl-ethyl)-thiazole in an acidic condition by adding an -5 - oxidizing agent under an -5 - 4 - acidic condition; and the method comprises the following steps: preparing -4 -4 - ethyl acetoxyethyl)-thiazole. The synthesis method is mild in overall reaction condition, simple in post-treatment and suitable for pilot scale test and industrial production. (by machine translation)
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- Synthesis of Heterocyclic Compounds from 3-Acetyl-3-chloropropyl Acetate
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The reaction of the potassium salt of 2-mercaptobenzimidazole with 3-acetyl-3-chloropropyl acetate afforded the novel heterocyclic compound 1.When solutions of 1 in deuteriodimethylsulfoxide or deuteriomethanol were allowed to stand at room temperatures for 15 minutes and 19 days, respectively, ring opening of 1 occured to give the precursor, 3-acetyl-3-(2-benzimidazolthio)propyl-1-ol.The treatment of 1 with p-fluorophenyl isocyanate furnished the carbanilate 2.The reaction of ammonium dithiocarbamate with the above chloroketone afforded the 2-thiazolethione 3.Possible mechanisms and supporting nmr, ir, mass spectral data for 1-3 and single crystal X-ray analysis for 2 are discussed.
- D'Amico, John J.,Bollinger, Frederic G.,Thompson, Michael,Freeman, John J.,Dahl, William E.,Pustinger, John V.
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p. 1193 - 1198
(2007/10/02)
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