- HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF
-
The present disclosure relates to inhibitors of one or more isoforms of RAS, such as inhibitors of one or more of KRAS, HRAS and NRAS, or mutants thereof, such as G12D, G12V, G13D or G12C mutants thereof. Therapeutic methods of treating conditions and dis
- -
-
Paragraph 0242; 0296
(2021/12/28)
-
- FUSED RING COMPOUNDS
-
This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.
- -
-
Paragraph 0905
(2020/06/01)
-
- Synthesis and structure-activity relationship of substituted 1,2,3,4- tetrahydroisoquinolines as N-type calcium channel blockers
-
Voltage Activated Calcium Channel (VACC) blockers have been demonstrated to have utility in the treatment of pain and stroke. A series of aminomethyl substituted isoquinolinol derivatives with potent functional activity for N- type VACC's have been identi
- Yuen, Po-Wai,Schelkun, Robert M.,Szoke, Balazs,Tarczy-Hornoch, Katalin
-
p. 2415 - 2418
(2007/10/03)
-
- BICYCLIC NITROGEN HETEROCYCLIC ETHERS AND THIOETHERS, AND THEIR PHARMACEUTICAL USES
-
A class of bicyclic nitrogen heterocyclic ether and thioether compounds exhibiting pharmacological activity including cytoprotective, H. sub.2-antagonist, anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions are disclosed.
- -
-
-
- BICYCLIC NITROGEN HETEROCYCLIC ETHERS AND THIOETHERS, AND THEIR PHARMACEUTICAL USES
-
A class of bicyclic nitrogen heterocyclic ether and thioether compounds exhibiting pharmacological activity including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions are disclosed.
- -
-
-