- An easy access to asymmetrically substituted oligoethylene glycols from 18-crown-6
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A new route for the preparation of multi-gram quantities of the heterobifunctional oligoethylene glycol (OEG) derivatives (n = 6, 7) is reported based on decyclization of 18-crown-6.
- Abronina, Polina I.,Zinin, Alexander I.,Orlova, Anna V.,Sedinkin, Sergey L.,Kononov, Leonid O.
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p. 4533 - 4535
(2013/08/23)
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- Method of inhibiting nonspecific interaction between molecules on solid phase support
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The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.
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