Direct Enamido C(sp2)?H Diphosphorylation Enabled by a PCET-Triggered Double Radical Relay: Access to gem-Bisphosphonates
Herein we report a novel and straightforward protocol for the construction of valuable gem-BPs by means of proton-coupled electron-transfer (PCET)-triggered enamido C(sp2)?H diphosphorylation. This reaction represents a rare example of realizing the challenging double C?P bond formation at a single carbon atom, thus providing facile access to a broad variety of structurally diverse bisphosphonates from simple enamides under silver-mediated conditions. Initial mechanistic studies demonstrated that the diphosphorylation involves two rounds of PCET-initiated radical relay process.
Versatile pyrrole synthesis through ruthenium(II)-catalyzed alkene C-H bond functionalization on enamines
An efficient ruthenium(II) catalyst enabled broadly applicable oxidative alkyne annulations with electron-rich enamines to provide diversely decorated pyrroles, even in an aerobic fashion with air as the ideal oxidant.
Wang, Lianhui,Ackermann, Lutz
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p. 176 - 179
(2013/04/10)
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