The discovery of potent and selective 4-aminothienopyridines as B-Raf kinase inhibitors
A series of novel, potent 4-aminothienopyridine B-Raf kinase inhibitors was designed and synthesized using knowledge-based design. Compounds 5f, and 6k exhibited not only excellent potency in both enzyme assay (IC50 = 5.1, 16.6 nM) and cellular
Tang, Jun,Lackey, Karen E.,Dickerson, Scott H.
p. 66 - 70
(2013/02/23)
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