Synthesis and antiviral evaluation of analogs of adenosine-N1-oxide and 1-(benzyloxy)adenosine
The activity of a series of compounds related to adenosine-N1-oxide (1) and 1-(benzyloxy)adenosine (42) against vaccinia virus has been determined both in vitro and in a vaccinia mouse tailpox model. Significant activities have been found both in vitro and in vivo for a number of the synthetic compounds.
Kwong, Cecil D.,Krauth, Charles A.,Shortnacy-Fowler, Anita T.,Arnett, Gussie,Hollingshead, Melinda G.,Shannon, William M.,Montgomery, John A.,Secrist III, John A.