- A near-infrared response of bionic nano-preparation and preparation method and application thereof
-
The present invention provides a near-infrared response of a bionic nanopharmaceutical. The bionic nanopharm comprises a cell membrane of an HBV hepatocyte model and a nanocarrier encased within the cell membrane, the nanocarrier comprising a near-infrared response of upconversion nanoparticles and CRISPR / Cas9, the upconversion nanoparticle surface modified with an affinity protein, the avidin protein and CRISPR / Cas9 are connected to a biotin-modified photolytic molecule. It solves the problems of CRISPR/Cas9 delivery system with high immunogenicity, low targeting, small carrying load and inability to achieve remote spatio-temporal operation in the existing technology. An efficient CRISPR/Cas9 delivery system with low immunogenicity, high targeting, large carrying load, and simple production and synthesis has been established, and the precise remote spatio-temporal operation of CRISPR/Cas9 has been implemented.
- -
-
Paragraph 0064-0066
(2022/01/12)
-
- Preparation of CaCO3 and CaO nanoparticles via solid-state conversion of calcium oleate precursor
-
Calcium carbonate (CaCO3) and monodisperse calcium oxide nanoparticles (CaO NPs) are prepared by the calcination of solid-state calcium oleate precursor in air condition. The effect of calcination temperature on the synthesis of CaCO3 and CaO NPs is examined. The polymorphism is confirmed by X-ray diffraction spectroscopy (XRD), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The sample morphologies including their size and size distribution are investigated by field emission scanning electron microscopy (FESEM). Calcination of calcium oleate between 400 and 550 °C results in CaCO3 NPs with mean sizes from 82 to 98 nm, whereas monodisperse spherical CaO NPs are obtained at 650 °C and an average size is estimated to be 40 nm. Beyond 650 °C, the size of CaO NPs increases with broad size distribution. The results of this study provide a novel approach to monodisperse CaCO3 and CaO NPs that can be applied in a variety of fundamental and industrial fields.
- Atchudan, Raji,Lone, Nasreena,Joo, Jin
-
p. 1958 - 1964
(2018/01/11)
-
- Characterisation of metal carboxylates by Raman and infrared spectroscopy in works of art
-
This work introduces the complementary use of μ-Raman and μ-Fourier transform infrared (IR) spectroscopy for the detection of specific carbon chains and cations for the identification of metal carboxylates within oil paint microsamples. Metal carboxylates (metal soaps) form naturally when free fatty acids react with metal cations and may also be found as additives or degradation products. Twenty-two metal carboxylates were synthesised, and their spectra assembled in a reference database. Metal salts of cations commonly present in oil paintings were used, including lead, zinc, calcium, cadmium, copper and manganese. The fatty acids selected were the saturated acids palmitic (C1 6:0) and stearic (C18:0) and the polyunsaturated oleic acid (C1 8:1). Azelaic acid (C9 diacid), a product resulting from autoxidation of polyunsaturated acids, was also included. Metal carboxylates were characterised by Raman and IR spectroscopy, and their structures were confirmed by X-ray diffraction. Raman and IR spectroscopy proved to be complementary techniques for a full identification of the metal carboxylates in complex aged paint. Raman enables the differentiation of the carbon chain length in the C-C stretching region (1120-1040 cm-1), and IR distinguishes the metal cation in the COO- stretching absorption region (1650-1380cm-1). Principal component analysis was applied to the spectra in order to facilitate a fast and accurate method to discriminate between the different metal carboxylates and to aide in their identification. Finally, spectra from case studies were successfully projected in the principal component analysis models built, enabling a higher confidence level for the identification of copper palmitate and copper azelate in two 19th-century Portuguese oil paintings.
- Otero, Vanessa,Sanches, Diogo,Montagner, Cristina,Vilarigues, Mrcia,Carlyle, Leslie,Lopes, Joo A.,Melo, Maria J.
-
p. 1197 - 1206
(2015/02/19)
-
- OVERBASED METAL CARBOXYLATE PRECURSOR AND PROCESS FOR MAKING
-
Shelf stable, flowable liquids of overbased alkaline earth metal salts are prepared by reacting an alkaline earth metal base and a carboxylic acid in the presence of a hydrocarbon liquid, a polyol and an alcohol. The resulting overbased alkaline earth metal salts have an alkaline earth metal content of at least about 14.5% and a non-volatile matter content of at least about 95%.
- -
-
Page/Page column 10-11
(2009/12/05)
-
- Liquid overbased mixed metal stabilizer composition of calcium, barium and zinc for stabilizing halogen-containing polymers
-
Liquid overbased calcium/barium/zinc ternary systems are provided for stabilizing halogen-containing polymers. These overbased ternary stabilizer systems are shelf stable liquids and provide polyvinyl chloride compositions with improvements in thermal stability, early color, clarity and plate-out resistance.
- -
-
-
- Kalorimetrische Untersuchungen zur Adsorption von Tensiden an Mineralen
-
A process for the separation of finely disseminated ores is the selective agglomerate flotation.In this technique surfactants are adsorbed at the mineral particles making their surface hydrophobic.In a second step the particles are tumbled in an aqueous solution containing an unmiscible bridging liquid which causes their selective agglomeration.The interaction between the adsorbed surfactant molecules and the mineral surface is decisive for high selectivity and recovery of the agglomeration process.This could be shown by calorimetric measurements of the heat of adsorption of sodiumoleate and sodiumhexadecylsulfate at scheelite and calcite.In adsorption of surfactants from aqueous solution at mineral surfaces effects as solubility of the minerals and the precipitate formation of surfactants with polyvalent ions have to be taken into account.By means of calorimetric measurements it could be distinguished, whether there is interaction between the mineral surface and adsorbed surfactant molecules, double layer adsorption or precipitate formation.
- Rybinski, W. von,Schwuger, M. J.
-
p. 1148 - 1152
(2007/10/02)
-