- Synthese des isocyanates de 2-F-alkylethyle
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Isocyanates are extremely important compounds in organic synthesis but their preparation is not always easy.One of the most convenient methods uses the acids as intermediates.In the F-alkyl series it is sometimes difficult to obtain them.We have optimized an efficient synthetic route to 2-F-alkylethyl isocyanates.
- Jouani, A. M.,Szoenyi, F.,Cambon, A.
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- NEW FLUOROUS TAGGING AND SCAVENGING REACTANTS AND METHODS OF SYNTHESIS AND USE THEREOF
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The present invention includes methods and compositions for increasing the fluorous nature of an organic compound by reacting it with at least one fluorous compound to produce a fluorous tagged organic compound. The increased fluorous nature of the fluorous tagged organic compound can then be utilized to separate the fluorous organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom. The resultant fluorous tagged organic compound can be subjected to subsequent chemical transformations, wherein the fluorous nature of the tagged compound is utilized to increase the ease of separation of the fluorous tagged organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom, after each chemical transformation. The chemical transformations result in a second fluorous tagged organic compound wherein the fluorous nature of the second fluorous tagged organic compound can then be reduced by removing the fluorous group therefrom, thereby producing a second organic compound that may be employed as a pharmaceutical compound or intermediate, or a combinatorial library component.
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- Synthesis and study of the behavior of glycosylated gemini surfactants in aqueous media
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The work reported herein deals with the synthesis and physico-chemical studies of a new kind of glycosylated non-ionic gemini surfactants. These compounds derive from tris(hydroxymethyl)aminomethane and bear hydro- or perfluorocarbon tails. The chemical structures of the spacer arm and hydrophobic tails were adjusted in order to specify their impact on the gemini surfactant behavior in aqueous media. The supramolecular systems they form were studied by TEM after negative staining. The length and the rigidity of the spacer arm seem to play a key role in the aggregation behavior of these surfactants in water. With the appropriate modifications, the formation of premicellar associations, micelles, vesicles or various aggregates can be observed.
- Wathier,Polidori,Ruiz,Fabiano,Pucci
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p. 1588 - 1599
(2007/10/03)
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