Diastereoselective synthesis of β-heteroaryl syn -α-methyl- β-amino acid derivatives via a double chiral auxiliary approach
The addition of the SuperQuat enolate to five- and six-membered heterocyclic tert-butyl sulfinimines led to a high syn-selectivity of up to 99:1 in good to excellent yields. The reaction is tentatively proposed to proceed through an open-chain transition
Bian, Jianwei,Blakemore, David,Warmus, Joseph S.,Sun, Jianmin,Corbett, Matthew,Rose, Colin R.,Bechle, Bruce M.
p. 562 - 565
(2013/03/29)
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