Synthesis of novel aliphatic N-sulfonylamidino thymine derivatives by Cu(I)-catalyzed three-component coupling reaction
A series of new aliphatic N-sulfonylamidino thymine derivatives containing nucleobase, N-sulfonyl and amidine pharmacophores in the structure were synthesized by Cu(I)-catalyzed three-component coupling of 1-propargyl thymine, benzenesulfonyl azides and a