- Cyclopentadecanone preparation method
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The invention provides a cyclopentadecanone preparation method. The method includes that cyclododecene and acryloyl chloride are subjected to reaction to obtain a ketene intermediate shown as a formula (II), the intermediate and a sulfuryl hydrazine compound are subjected to reaction to obtain a hydrazone intermediate shown as a formula (III), and the hydrazone intermediate is subjected to ring opening and hydrogenation to obtain a cyclopentadecanone product shown as a formula (V). Compared with a traditional cyclopentadecanone synthesis route, the method mainly has advantages of low cost andeasiness in acquisition of starting materials, the ketene intermediate shown as the formula (II) is obtained by high-selectivity reaction of cyclododecene and acryloyl chloride, and the integral synthesis route is simple and short in step, high in total yield and applicable to cyclopentadecanone industrial production.
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- An Electrochemical Variant in the Syntheses of Exaltone and Muscone: Anodic Fragmentation of α,β-Unsaturated Tosylhydrazones
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Ring enlargement of bicyclopentadec-1(12)-en-13-one p-toluenesulfonylhydrazone into cyclopentadec-4-yn-1-one was accomplished under mild and controlled anodic oxidation conditions.The mechanism of this fragmentation is reconsidered.
- Limacher, Liviana L.,Delay, Francois D.,Bedert, Nicole,Tissot, Paul
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p. 1383 - 1389
(2007/10/02)
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