- PROCESS FOR THE PURIFICATION OF OPTICALLY IMPURE 2-(2-(3(S)-(3-(7-CHLORO-2-QUINOLINYL)ETHENYL)PHENYL)-3-HYDROXY-PROPYL)PHENYL-2-PROPANOL
-
A process for purifying an optically impure 2-(2-(3(S)-(3-(7-chloro-2-quinolinyl)- ethenyl)-phenyl)-3-(hydroxylpropyl)phenyl)-2 propanol is disclosed. The purified compound typically has an enantiomeric excess higher than 99%, and can be used to prepare montelukast and salts thereof.
- -
-
Page/Page column 7
(2009/01/20)
-
- Process for the preparation of leukotriene anatgonists
-
The present invention relates to a process for the preparation of a compound of formula (I) or a sodium salt thereof STR1 wherein HET is 7-chloroquinolin-2-yl or 6,7-difluoroquinolin-2-yl, which comprises: reacting the dilithium dianion of 1-(mercaptomethyl)cyclopropaneacetic acid with a compound of formula (II) STR2 wherein HET is as defined above and L is arylsulfonyl or alkylsulfonyl. The invention further provides the dicyclohexylamine salt of a compound of formula (I).
- -
-
-
- Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
-
Compounds having the formula I: STR1 are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
- -
-
-
- Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
-
Compounds having the formula I: STR1 are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
- -
-
-