Quantum Tunneling Mediated Interfacial Synthesis of a Benzofuran Derivative
Reaction pathways involving quantum tunneling of protons are fundamental to chemistry and biology. They are responsible for essential aspects of interstellar synthesis, the degradation and isomerization of compounds, enzymatic activity, and protein dynami
Paintner, Tobias,Bj?rk, Jonas,Du, Ping,Klyatskaya, Svetlana,Paszkiewicz, Mateusz,Hellwig, Raphael,Uphoff, Martin,?ner, Murat A.,Cuniberto, Edoardo,Deimel, Peter S.,Zhang, Yi-Qi,Palma, Carlos-Andres,Allegretti, Francesco,Ruben, Mario,Barth, Johannes V.,Klappenberger, Florian
Synthesis and biological activity of the metabolites of diethyl 4-[(4- bromo-2-cyanophenyl)carbamoyl]benzylphosphonate (NO-1886)
Five metabolites of diethyl 4-[(4-bromo-2- cyanophenyl)carbamoyl]benzylphosphonate (NO-1886) (1) were synthesized to confirm their proposed structures. The metabolites (2-6) were found to be identical with the synthesized compounds. These metabolites were
Goto,Nakamura,Morioka,Kondo,Naito,Tsutsumi
p. 547 - 551
(2007/10/03)
Structure-activity relationship of a series of phenylureas linked to 4- phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O- acyltransferase with antiatherosclerotic activity. 2
In our continuing search to find systemically bioavailable ACAT (acyl- CoA:cholesterol O-acyl-transferase) inhibitors with more potent antiatherosclerotic effect than N-[2-(dimethylamino)-6-[3-(5-methyl-4- phenyl-1H-imidazol-1-yl)propoxy]phenyl]-N'-pentyl