Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule
This Letter describes the further optimization of an MLPCN probe molecule (ML137) through the introduction of 5- and 6-membered spirocycles in place of the isatin ketone. Interestingly divergent structure-activity relationships, when compared to earlier M
Poslusney, Michael S.,Melancon, Bruce J.,Gentry, Patrick R.,Sheffler, Douglas J.,Bridges, Thomas M.,Utley, Thomas J.,Daniels, J. Scott,Niswender, Colleen M.,Conn, P. Jeffrey,Lindsley, Craig W.,Wood, Michael R.
p. 1860 - 1864
(2013/04/10)
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