A simple enantioselective route toward (R)- and (S)-Rolipram via anhydride desymmetrization
A highly enantioselective metal-free synthesis of both enantiomers of Rolipram is reported. The key stereoinductive step is a cinchona alkaloid catalyzed opening of a cyclic anhydride prepared from isovanillin, where both enantiomers are available using t
Ivsic, Trpimir,Hamersak, Zdenko
p. 217 - 222
(2013/04/23)
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