GC-Targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models
DNA binding 4-(1-methyl-1H-pyrrol-3-yl)benzenamine (MPB) building blocks have been developed that span two DNA base pairs with a strong preference for GC-rich DNA. They have been conjugated to a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) molecule to produce
Rahman, Khondaker M.,Jackson, Paul J. M.,James, Colin H.,Basu, B. Piku,Hartley, John A.,De La Fuente, Maria,Schatzlein, Andreas,Robson, Mathew,Pedley, R. Barbara,Pepper, Chris,Fox, Keith R.,Howard, Philip W.,Thurston, David E.
p. 2911 - 2935
(2013/05/23)
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