Synthesis and pharmacological characterization of two novel, brain penetrating P2X7 antagonists
The synthesis and preclinical characterization of two novel, brain penetrating P2X7 compounds will be described. Both compounds are shown to be high potency P2X7 antagonists in human, rat, and mouse cell lines and both were shown to
Letavic, Michael A.,Lord, Brian,Bischoff, Francois,Hawryluk, Natalie A.,Pieters, Serge,Rech, Jason C.,Sales, Zachary,Velter, Adriana I.,Ao, Hong,Bonaventure, Pascal,Contreras, Victor,Jiang, Xiaohui,Morton, Kirsten L.,Scott, Brian,Wang, Qi,Wickenden, Alan D.,Carruthers, Nicholas I.,Bhattacharya, Anindya
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p. 419 - 422
(2013/06/26)
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