- PYRIMIDINE AND PYRIDINE DERIVATIVES USEFUL IN THERAPY
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The invention provides compounds of formula (I), wherein one of X, Y and Z represents N and the other two represent CH, or X=Y-Z represents N=CH-N; W represents a CI-6 alkylene group which may be straight or branched; R1 represents H, phenyl, naphthyl, heteroaryl1, heterocyclyl1 or C3-6 cycloalkyl; wherein each phenyl, naphthyl, heteroaryl', heterocyclyl1 and C3-6 cycloalkyl group is optionally substituted, and wherein each phenyl, naphthyl, heteroaryl1, heterocyclyl1 and C3-6 cycloalkyl group is optionally fused to a 5- or 6-membered heteroaromatic or heterocyclic ring containing from 1 to 3 heteroatoms (selected from N, O and S); and each heteroaryl1, heterocyclyl1 and C3-6 cycloalkyl group is optionally fused to a benzene ring; m is 1 or 2; n is 0, 1 or 2; A is C=O or SO2; V represents a bond or C1-8 alkylene which may be straight or branched; R2 represents H, -S-(C1-6 alkyl), -SO2N(C1-6 alkyl)2, -CO2-(C1-6 alkyl), - NHCOCH2-phenyl, -OCH2- phenyl, -S02-phenyl, -NR3R4, phenyl, naphthyl, heteroaryl2, heterocyclyl2, -CO-heterocyclyl2 or C3-6 cycloalkyl; wherein each phenyl, naphthyl, heteroaryl2, heterocyclyl2 and C3-6 cycloalkyl group is optionally substituted, and wherein each phenyl, naphthyl, heteroaryl2, heterocyclyl2 and C3-6 cycloalkyl group is optionally fused to a 5- or 6-membered heteroaromatic or heterocyclic ring containing from 1 to 3 heteroatoms (selected from N, O and S); and wherein each heteroaryl2, heterocyclyl2 and C3-6 cycloalkyl group is optionally fused to a benzene ring; and pharmaceutically acceptable salts and solvates thereof. The compounds are useful as pharmaceuticals, particularly in the treatment of fibrotic diseases, cancer and pain.
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