Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: A correction
The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2- phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.
Goldmann,Stoltefuss,Born
p. 3341 - 3344
(2007/10/02)
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