- Synthesis and antitumor activity of 10-substituted benzylidene anthrone
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Fifteen compounds of 10-substituted benzylidene anthrone were prepared with moderate yield by reaction of anthrone and substituted benzaldehydes under the presence of pyridine and piperidine as catalyst. Their antitumor activities in vitro were evaluated.
- Hu, Weixiao,Zhou, Wei
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- An expedient regio- and diastereoselective synthesis of hybrid frameworks with embedded spiro[9,10]dihydroanthracene [9,3']-pyrrolidine and Spiro[oxindole-3,2'-pyrrolidine] motifs via an ionic liquid-mediated multicomponent reaction
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A series of hitherto unreported anthracene-embedded dispirooxindoles has been synthesized via a one-pot three-component 1,3-dipolar cycloaddition reaction of an azomethine ylide, generated in situ from the reaction of isatin and sarcosine to 10-benzyliden
- Arumugam, Natarajan,Almansour, Abdulrahman I.,Kumar, Raju Suresh,Menéndez, J. Carlos,Sultan, Mujeeb A.,Karama, Usama,Ghabbour, Hazem A.,Fun, Hoong-Kun
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- Characterization of a new class of androgen receptor antagonists with potential therapeutic application in advanced prostate cancer
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The human androgen receptor plays a major role in the development and progression of prostate cancer and represents a well-established drug target. All clinically approved androgen receptor antagonists possess similar chemical structures and exhibit the s
- Li, Huifang,Hassona, Mohamed D.H.,Lack, Nathan A.,Axerio-Cilies, Peter,Leblanc, Eric,Tavassoli, Peyman,Kanaan, Natalia,Frewin, Kate,Singh, Kriti,Adomat, Hans,Boehm, Konrad J.,Prinz, Helge,Guns, Emma Tomlinson,Rennie, Paul S.,Cherkasov, Artem
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p. 2425 - 2435
(2013/12/04)
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- A facile synthesis of homotriptycenes from anthranol derivatives
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Substituted trans-10-benzyl-9-anthranols 5a,b and substituted 10, 10-dibenzyl-9-anthranol 8e undergo intramolecular cyclization in the presence of formic or oxalic acid to give homotriptycenes 9a,b,e. Depending on the amount of acid used, a competitive 1,
- Cao, Derong,Gao, Chunmei,Meier, Herbert
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p. 3166 - 3168
(2007/10/03)
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- Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization
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A novel series of 10-benzylidene-9(10H)-anthracenones and 10-(phenylmethyl)-9(10H)-anthracenones were synthesized and evaluated for antiproliferative activity in an assay based on K562 leukemia cells. The 3-hydroxy-4-methoxybenzylidene analogue 9h was fou
- Prinz, Helge,Ishii, Yukihito,Hirano, Takeo,Stoiber, Thomas,Camacho Gomez, Juan A.,Schmidt, Peter,Düssmann, Heiko,Burger, Angelika M.,Prehn, Jochen H. M.,Günther, Eckhard G.,Unger, Eberhard,Umezawa, Kazuo
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p. 3382 - 3394
(2007/10/03)
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- A facile synthesis of 10-arylmethylene anthracenones under microwave irradiation
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10-Arylmethylene anthracenones were synthesised by the condensation of aromatic aldehydes with anthracenone using sodium hydroxide as catalyst under microwave irradiation in good yields.
- Zhou,Tu,Feng
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p. 414 - 415
(2007/10/03)
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- Thermolysis of 2-Benzylidenebenzocyclobutenols
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The thermolysis of a series of 2-benzylidenebenzocyclobuten-1-ols has been studied.Whenever comparisons can be made, the rate of opening of the benzocyclobutene ring was slower for these compounds than the corresponding 2-ones.The intermediate vinylallenes underwent a variety of electrocyclization reactions which depended on the nature of the additional substituent at C-1. 10-Benzylideneanthrone and 4-benzylidene-1-tetralones, respectively, were obtained when this substituent was phenyl or vinyl. 1-(Alkynylphenyl)-2-benzylidenebenzocylobuten-1-ols were converted to mixtures of 4-benzylidene-1,4-naphthoquinonemethides, 2,3-dibenzylidene-1-indanones, and 10-phenylbenzofluorenone.
- Bradley, Jean-Claude,Durst, Tony,Williams, A. J.
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p. 6575 - 6579
(2007/10/02)
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