Highly Potent, Orally Active Diester Macrocyclic Human Renin Inhibitors
Replacing one amide bond in macrocyclic renin inhibitors of the general structure 1 and 2 with an ester linkage gave glutamate-derived inhibitors 3 and serine-derived inhibitors 4.While this oxygen-for-nitrogen exchange had little effect on potency in the
Weber, Ann E.,Steiner, Mark G.,Krieter, Philip A.,Colletti, Adria E.,Tata, James R.,et al.
p. 3755 - 3773
(2007/10/02)
More Articles about upstream products of 143508-14-9