- COMPOUNDS AND METHODS FOR HEMATOPOIETIC REGENERATION
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The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.
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Page/Page column 76
(2019/06/17)
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- Efficient two-step access to azafluorenones and related compounds
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Crystals of a lithiocuprate prepared from copper(I) chloride and lithium 2,2,6,6-tetramethylpiperidide (2 equiv) were isolated and analyzed by X-ray diffraction as (TMP)2Cu(Cl)Li2·THF. The observation of this species is consistent with its having a role in deprotocupration- aroylation. Phenyl pyridyl ketones, phenyl quinolyl ketones, and phenyl thienyl ketones were prepared in tetrahydrofuran using the lithiocuprate and aroyl chorides as electrophiles. Diaryl ketones bearing a chloro group at the 2 position (of a pyridyl or phenyl group) thus synthesized were next converted through palladium-catalyzed ring closure to polycycles of the 5H-indeno[1,2-b]pyridin-5-one, 11H-indeno[1,2-b]quinolin-11-one, 9H-indeno[2,1-c]pyridin-9-one, and 8H-indeno[2,1-b]thiophen-8-one families.
- Marquise, Nada,Harford, Philip J.,Chevallier, Floris,Roisnel, Thierry,Wheatley, Andrew E.H.,Gros, Philippe C.,Mongin, Florence
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p. 3154 - 3157
(2013/06/27)
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- Synthesis of azafluorenones and related compounds using deprotocupration-aroylation followed by intramolecular direct arylation
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The efficiency of the deprotocupration-aroylation of 2-chloropyridine using lithiocuprates prepared from CuX (X=Cl, Br) and LiTMP (TMP=2,2,6,6- tetramethylpiperidido, 2 equiv) was investigated. CuCl was identified as a more suitable copper source than CuBr for this purpose. Different diaryl ketones bearing a halogen at the 2 position of one of the aryl groups were synthesized in this way from azines and thiophenes. These were then involved in palladium-catalyzed ring closure: substrates underwent expected CH-activation-type arylation to afford fluorenone-type compounds, and were also subjected to cyclization reactions leading to xanthones, notably in the presence of oxygen-containing substituents or reagents.
- Marquise, Nada,Harford, Philip J.,Chevallier, Floris,Roisnel, Thierry,Dorcet, Vincent,Gagez, Anne-Laure,Sablé, Sophie,Picot, Laurent,Thiéry, Valérie,Wheatley, Andrew E.H.,Gros, Philippe C.,Mongin, Florence
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p. 10123 - 10133
(2013/11/06)
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