- MODULATORS OF CASPASE-6
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The current application relates to a pharmaceutical composition for the treatment or amelioration of a neurological disease, wherein the composition comprises a therapeutically effective amount of a caspase-6 inhibitor which is an arylpropynamide derivative. The composition can be formulated for oral or topical administration, subcutaneous, intravenous, or intramuscular injection, infusion, inhalation, or intrthecal injection.
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Paragraph 000185; 000190-000191
(2016/04/26)
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- Preparation of arylpropynamides and their reaction with malonyl acid derivatives
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Synthesis of arylpropynamides and their reactions with different malonic acid derivatives is described. Treatment of arylpropynamides with unsubstituted malonyl chloride furnished N-(3-arylprop-2-ynoyl)-6-chloro-4-hydroxy-2-oxo-2H- pyran-3-carboxamides; m
- Petina, Olgaa. A.,Yakovlev, Igorp. P.,Geffken, Detlef
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p. 803 - 809
(2013/04/10)
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