Palladium-catalyzed heck-type coupling via C-N cleavage
Abstract A palladium-catalyzed Heck-type coupling method between arenes and ketone Mannich bases via C-N cleavage to synthesize chalcones is reported. This protocol offers good yields and tolerates a broad range of functional groups. Based on the extensive experimental data, we propose a plausible coulping mechanism.
Fan, Weizheng,Liu, Faming,Feng, Bainian
p. 1253 - 1257
(2015/06/02)
Pd-catalyzed C-H olefination of (hetero)arenes by using saturated ketones as an olefin source
Tolerant: By using Pd(OAc)2/PCy3 as a catalyst, both electron-rich aromatic heterocycles and electron-deficient fluorobenzenes undergo the dehydrogenative cross-coupling with (hetero)aryl ethyl ketones in good yields. A broad range of functional groups is tolerated, thus providing a general method for the facile syntheses of chalcones or heterocyclic chalcone analogues. Furthermore, dialkyl ketones can also participate in this transformation. Copyright