Synthesis of α,α-Disubstituted α-Amino Acid Amides by Phase-Transfer Catalyzed Alkylation
α,α-Disubstituted α-amino acid amides were prepared in 17-88 percent chemical yield by the phase-transfer catalyzed alkylation of N-benzylidene α-H amino acid amides, followed by weak acidic hydrolysis of the Schiff bases.
Kaptein, Bernard,Boesten, Wilhelmus H. J.,Broxterman, Quirinus B.,Schoemaker, Hans E.,Kamphuis, Johan
p. 6007 - 6010
(2007/10/02)
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