Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole intermediate compounds
Compounds of the general formula I: STR1 are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.
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(2008/06/13)
HMG-CoA Reductase Inhibitors: Design, Synthesis, and Biological Activity of Tetrahydroindazole-Substituted 3,5-Dihydroxy-6-heptenoic Acid Sodium Salts
Compounds comprising a series of 7--3,5-dihydroxy-6-heptenoic acid sodium salts (18) were synthesized and tested for their ability to inhibit HMG-CoA reductase in a partially purified enzyme preparati
Connolly, Peter J.,Westin, Claudia D.,Loughney, Deborah A.,Minor, Lisa K.
p. 3674 - 3685
(2007/10/02)
TETRAHYDROINDAZOLE, TETRAHYDROCYCLOPENTAPYRAZOLE, AND HEXAHYDROCYCLOHEPTAPYRAZOLE COMPOUNDS AND THEIR USE AS HMG-COA REDUCTASE INHIBITORS
Compounds of the general formula I: STR1 are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.
-
(2008/06/13)
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