Conformation and atropisomeric properties of indometacin derivatives
The stereochemistry around the N-benzoylated indole moiety of indometacin was studied by restricting the rotation about the N-C7′ and/or C7′-C1′ bond. In the 2′,6′-disubstituted ones, an atropisomeric property was found and the atropoisomers were separate