Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents
CCG-1423 (1) is a novel inhibitor of Rho/MKL1/SRF-mediated gene transcription that inhibits invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. We recently reported the design and synthesis of conformationally restricted analogs (e.g
Bell, Jessica L.,Haak, Andrew J.,Wade, Susan M.,Kirchhoff, Paul D.,Neubig, Richard R.,Larsen, Scott D.
p. 3826 - 3832
(2013/07/25)
More Articles about upstream products of 1443437-79-3