- Regioselective lipase-catalyzed synthesis of L-glutamic α-monoamide derivatives. Effect of the N-blocking group
-
Several Block-L-Glu(OEt)-OEt (Block = amides, carbamates and trityl group) have been subjected to an aminolysis reaction catalyzed by the lipase B of Candida antarctica. The reaction took place in a regioselcctive manner and α-monoamides were obtained in all cases (except the bulky trityl group that did not react). Besides (he synthetic value of the method, the results may empirically point out to some features of tile active site of the enzyme as the reaction rate was severely affected by volume and electronic characteristics of the blocking group.
- Conde, Santiago,Lopez-Serrano, Paloma,Fierros, Marta,Biezma, Maria Isabel,Martinez, Ana,Rodriguez-Franco, Maria Isabel
-
-
Read Online
- A Simple and Efficient Esterification Method
-
A convenient and practical esterification was realized and this reaction proceeded without a dehydrating reagent or water removal equipment. The synthesis of esters by reaction of carboxylic acids with various alcohols such as methyl, ethyl, isopropyl, isobutyl, allyl, benzyl, propargyl and decanyl alcohols were achieved with a catalytic amount of CBr4 under refluxing reaction condition.
- Ming-Yi, Chen,Lee, Adam Shih-Yuan
-
p. 103 - 108
(2007/10/03)
-