Direct N-cyclopropylation of secondary acyclic amides promoted by copper
The N-cyclopropylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper system. The corresponding tertiary acyclic amides, which constitute a wide family of biologically active compounds, have been obtained in good to excellent yields.
Racine, Emilie,Monnier, Florian,Vors, Jean-Pierre,Taillefer, Marc
p. 7412 - 7414
(2013/09/23)
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