Synthesis of 10-aryl- and 10-(arylmethyl)acridin-9(10H)-ones via the reaction of (2-fluorophenyl)(2-halophenyl)methanones with benzenamines and arylmethanamines
The reaction of 1-fluoro-2-lithiobenzenes, generated from 1-bromo-2-fluorobenzenes 1 and BuLi, with 2-halobenzaldehydes and subsequent oxidation of the resulting alcohols 2 afforded (2-fluorophenyl)(2-halophenyl) methanones 3, which, on treatment with ben