- Tetrahydropyrrole compound, preparation method, pharmaceutical composition and application thereof
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The invention discloses a tetrahydropyrrole compound and a preparation method, a pharmaceutical composition and application thereof. The tetrahydropyrrole compound of the invention is as shown in thegeneral formula (I). The tetrahydropyrrole compound of the invention has an excellent inhibitory effect on the positive symptom of schizophrenia, and has equivalent or stronger efficacy in comparisonwith the positive medicine olanzapine. In addition, the compound of the invention has a dual inhibitory effect on a D2 receptor and a DAT receptor, can effectively treat schizophrenia and improve negative symptoms and cognitive functions, and helps reduce side-effect of centrum and secretion of lactogen.
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- 3-Arylpyrrolidines via azomethine ylide 1,3-dipolar cycloaddition to styrenes
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Monosubstituted olefins conjugated to an aromatic or heteroaromatic ring undergo 1,3-dipolar cycloaddition with the azomethie ylide derived from N-benzyl-N-(methoxymethyl)trimethylsilylamine to give 3-aryl- and 3-hetero-arylpyrrolidines in good to excellent yield.
- Laborde, Edgardo
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p. 6607 - 6610
(2007/10/02)
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