- Glycerol and Q-tubes: Green catalyst and technique for synthesis of polyfunctionally substituted heteroaromatics and anilines
-
The role of glycerol as a green bio-based solvent, reactant, and/or a catalyst in the synthesis of novel heterocycles, under pressure, is studied. Synthesis of novel quinolines in good yields using a new modified Skraup synthesis, utilizing glycerol and pressure Q-tubes, is demonstrated. Novel aniline trimers are prepared using glycerol, and substituted anilines under pressure, in acidic medium and water. Glycerol was employed as a catalyst and a green solvent in the synthesis of novel pyridazines 13a-c. The mechanisms of the reactions and the catalytic effect of glycerol in protic and aprotic media are fully discussed. The structures of the synthesized compounds were determined via X-ray crystallography and spectroscopic methods.
- AlMarzouq, Douaa Salman,Elnagdi, Noha M. Hilmy
-
-
- Effects of oligofluorine substitution on the mutagenicity of quinoline: A study with twelve fluoroquinoline derivatives
-
A total of 12 variously fluorinated derivatives of quinoline (Q) were tested for their mutagenicity in Salmonella typhimurium TA100 in the presence of S9 mix to investigate the structure-mutagenicity relationship in oligofluorinated quinolines. Nine of th
- Kato, Taka-Aki,Saeki, Ken-Ichi,Kawazoe, Yutaka,Hakura, Atsushi
-
p. 149 - 157
(2007/10/03)
-