The present invention provides novel processes for the preparation of N-substituted benzamides having the formula (VIc). In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.
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Paragraph 0078
(2015/02/18)
PROCESS FOR PREPARATION OF ROFLUMILAST
The present invention provides novel processes for the preparation of N-substituted benzamides having the formula (VIc). In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.
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Paragraph 0050
(2013/09/26)
PREPARATION METHOD OF ROFLUMILAST
The present invention provides novel processes for the preparation of N-substituted benzamides having the formula VIc: (formula) In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.
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Paragraph 0043
(2013/09/26)
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