- A Machine-assisted flow synthesis of SR48692: A probe for the investigation of neurotensin receptor-1
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Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor-1 antagonist, with its machine-assisted flow chemistry alternative. By using these enabling tools, combined with solid-supported reagents and scavengers, many process advantages were observed. Care, however, must be taken not to convert these techniques into expensive solutions to problems that do not exist. Copyright
- Battilocchio, Claudio,Deadman, Benjamin J.,Nikbin, Nikzad,Kitching, Matthew O.,Baxendale, Ian R.,Ley, Steven V.
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p. 7917 - 7930
(2013/07/19)
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- The synthesis of neurotensin antagonist SR 48692 for prostate cancer research
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An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.
- Baxendale,Cheung,Kitching,Ley,Shearman
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p. 4378 - 4387
(2013/07/27)
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