- General synthesis of β-alanine-containing spider polyamine toxins and discovery of Nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors
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Certain spiders contain large pools of polyamine toxins, which are putative pharmacological tools awaiting further discovery. Here we present a general synthesis strategy for this class of toxins and prepare five structurally varied polyamine toxins. Elec
- Lucas, Simon,Poulsen, Mette H.,N?rager, Niels G.,Barslund, Anne F.,Bach, Tinna B.,Kristensen, Anders S.,Str?mgaard, Kristian
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- Facile synthesis of 6-hydroxyindole-3-acetic acid: On the structure of the aromatic subunit of nephilatoxin-1~6
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A facile synthesis of 6-hydroxyindole-3-acetic acid 1a, which is the proposed aromatic subunit of NPTX-1~6, is described. Radical cyclization of isonitrile 2 successfully afforded 9 in high yield. The aromatic subunit of NPTX-1~6 was confirmed as 4-hydroxyindole-3-acetic acid 12 by comparison of the 1H-NMR spectra with those of authentic 4- and 6-hydroxyindole-3-acetic acids.
- Shinada, Tetsuro,Miyachi, Miki,Itagaki, Yasuhiro,Naoki, Hideo,Yoshihara, Kazuo,Nakajima, Terumi
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p. 7099 - 7102
(2007/10/03)
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- Characterization and synthesis of a new calcium antagonist from the venom of a fishing spider
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A new calcium antagonist, CNS 2103, is isolated from the venom of a fishing spider, Dolomedes okefinokensis. The structure of this compound is derived from spectroscopic data, including tandem mass spectrometry. A flexible, convergent synthesis of CNS 2103 is described.
- McCormick, Kevin D.,Kobayashi, Kazumi,Goldin, Stanley M.,Laxma Reddy,Meinwald, Jerrold
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p. 11155 - 11168
(2007/10/02)
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