Novel Nonopioid Non-Antiinflammatory Analgesics: 3-(Aminoalkyl)- and 3-oxazolopyridin-2(3H)-ones
A series of 3-(aminoalkyl)- and 3-oxazolopyridin-2(3H)-ones were prepared from their respective oxazolopyridin-2(3H)-ones. Several members of this group were found to possess potent analgesic activity in the mouse during a p-phenylquinone writhing induced test. Among them, phenylpiperazine compounds with two-carbon length alkyl chains, 2a and 2b, appeared by high analgesic with little toxicity having neither an antiinflammatory effect nor opioid receptor affinity. The synthesis and structure-affinity relationships for this series are detailed.