Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties
The synthesis of a new series of oxazolidinones having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the oxazolidinone ring was investigated. A particular compound Ih having fluoro group showed the most potent antibacterial activity.
Kim, So-Young,Park, Hyeong Beom,Cho, Jung-Hyuck,Yoo, Kyung Ho,Oh, Chang-Hyun
scheme or table
p. 2558 - 2561
(2010/03/03)
Synthesis and In-Vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties
The synthesis of a new series of 1β-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in-vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. Most compounds were shown to be more active than the compared meropenem and imipenem against Escherichia coli. One particular compound, IIIb, having hydroxy a moiety showed the most potent antibacterial activity.
Park, Hyeong Beom,Jo, Nam Hyun,Hong, Joon Hee,Chei, Jung Hoon,Cho, Jung-Hyuck,Yoo, Kyung Ho,Oh, Chang-Hyun
p. 530 - 537
(2008/12/21)
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