- BENZIMIDAZOLE DERIVATIVES AND AZA-BENZIMIDAZOLE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF
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The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., Janus kinase (JAK), e.g., Janus kinase 2 (JAK2)) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating a disease (e.g., proliferative disease) in a subject in need thereof).
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Paragraph 00225; 00263
(2020/06/01)
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- Benzimidazole compound, and preparation method, intermediate and application thereof
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The invention discloses a benzimidazole compound, and a preparation method, an intermediate and an application thereof. The invention provides a benzimidazole compound A or a pharmaceutically-acceptable salt thereof, and also provides an application of th
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